Amell married his first wife, fellow Canadian Carolyn Lawrence, on December 8, 2007, in Toronto. The couple divorced in 2010. Amell married actress and model Cassandra Jean on December 25, 2012, in a private ceremony in the Caribbean, and for a second time in New Orleans on May 26, 2013. The couple has a daughter, Mavi, born in 2013.
Growing up, Amell was a fan of various local sporting teams, such as the Toronto Maple Leafs, Toronto Raptors, and the Toronto Blue Jays. Amell is still very involved with sports; in 2015, Amell campaigned to have Jays’ third baseman Josh Donaldson elected to the 2015 Major League Baseball All-Star Game. Since moving to Los Angeles, Amell has supported the LA Kings, and more recently, the LA Rams. During a visit to Dublin in May 2017, Amell attended the Dublin derby in Dalymount Park, after which he became a member of Bohemian F.C.
Amell and his business partner own Nocking Point, a wine company based out of Walla Walla, Washington. In 2015, Amell and James Frazier (owner of Walker Stalker conventions), began Heroes and Villains Fan Fest (HVFF), with their inaugural event taking place in San Jose in November of that year. The pair now run regular HVFF conventions, featuring actors/artists/writers from both Arrowverse and other comics-based shows/films